Get patients the medications they need sooner by integrating accurate, consistently formatted prescription data into existing software. Leverage the nation’s largest and most active e-prescribing network, connecting virtually all electronic health records (EHRs), health systems, pharmacies, health information exchanges and long-term and post-acute care facilities.
In-workflow tools help pharmacists and prescribers collaborate efficiently using NCPDP-defined transactions, including NewRx, RxFill, RxChange, RxTransfer, RxRenewal, NewRxRequest and CancelRx. Tap into industry-leading patient matching, automation that intelligently structures prescription data, and other innovations built to help improve medication adherence and patient safety.
e-prescriptions filled in 2023, including 21 million specialty prescriptions 1
of discontinued medications successfully canceled at the pharmacy after implementing CancelRx 2
RxChange transactions in 2023, enabling pharmacist/prescriber collaboration 1
A closer lookChoose your organization type to see how E-Prescribing can help you access trusted patient and prescription data via a network designed for seamless collaboration at scale.
Get clear, electronic prescriptions, reducing the need for phone calls, faxes and interpreting prescriber handwriting. Streamline collaboration with prescribers and get patients started on the right medication—and the path to adherence—sooner.
Enable safe, more efficient prescription management by standardizing transactions and reducing the need to clarify intent.
Reduce the potential for prescription abandonment, fraud and other safety issues by receiving prescriptions via the highly secure and powerful Surescripts network.
Collaborate on prescriptions within a single workflow, reducing administrative burden and avoiding miscommunication.
Use RxRenewal to request prescription renewals and propose updates such as a therapeutic alternative or change in days’ supply with RxChange.
The NewRx transaction leverages sophisticated e-prescription fields that reduce the need for follow-up.
Use RxChange to alert prescribers about generic substitutions and other alternatives, prior authorization and more.
Less need for data entry and follow-up means patients get prescriptions sooner. RxFill keeps the prescriber informed.
Send an RxRenewal or a NewRxRequest to the prescriber on behalf of the patient.
If the patient changes pharmacy locations, use RxTransfer to send the prescription to a different pharmacy.
Add E-Prescribing to your EHR to improve prescription speed, safety and accuracy for an exceptional care experience. Streamline collaboration with pharmacists and get patients started on the right medication and the path to adherence sooner.
Automate key transactions, streamline prescriber/pharmacist communication and build the foundation for additional functionality such as medication cost insights.
Eliminate the need for paper and let your users collaborate with pharmacists within the same prescription workflow.
Reduce the potential for prescription errors, abandonment, fraud and other safety issues by sending prescriptions via the highly secure and powerful Surescripts network.
Connect to virtually all U.S. pharmacies with verified, accurate contact information.
Formatted with standards built for clarity and safety, the prescription is routed to the patient’s preferred pharmacy.
RxChange lets prescribers review and quickly respond to questions and recommendations from the pharmacy.
The RxFill transaction provides certainty that the patient has picked up their medication.
When a pharmacy sends a renewal or new prescription request on behalf of the patient, it’s easy to approve in the EHR.
CancelRx tells the pharmacy to discontinue prescriptions or refills that the patient no longer needs.
Put patients at the center of care and get them the medications they need faster. Add E-Prescribing to your EHR to streamline collaboration with pharmacists and improve prescription speed, safety and accuracy for an exceptional care experience.
Eliminate the need for paper, phone calls and faxes by managing and updating all prescriptions within the same workflow.
Get patients on medication—and keep them taking it as prescribed. When E-Prescribing is combined with Eligibility & Formulary, first-fill medication adherence increases by 20%. 3
Reduce the potential for prescription errors, abandonment, fraud and other safety issues by sending prescriptions via the highly secure and powerful Surescripts network.
Use CancelRx to ensure discontinued prescriptions aren’t filled, and implement RxChange to quickly respond to recommendations from the pharmacy.
Formatted with standards built for clarity and safety, the prescription is routed to the patient’s preferred pharmacy.
RxChange lets prescribers review and quickly respond to questions and recommendations from the pharmacy.
The RxFill transaction provides certainty that the patient has picked up their medication.
When the pharmacy sends a renewal or new prescription request on behalf of the patient, it’s easy to approve in the EHR.
CancelRx tells the pharmacy to discontinue prescriptions or refills that the patient no longer needs.
Bring E-Prescribing into long-term and post-acute care workflows to get the right medications to patients faster. Securely communicate across care settings—including skilled nursing facilities, home health, hospice and transitional care—using specialized transactions including Census, Resupply, Recertification and Drug Administration.
Replace faxes and phone calls that can delay patient care with swift, secure prescribing.
Reduce the potential for prescription fraud and other safety issues by receiving prescriptions via the highly secure and powerful Surescripts network.
Simplify workflows with a single connection to pharmacies nationwide.
Integrate e-prescribing seamlessly into existing clinician workflows to save significant time and effort.
The discharging prescriber sends prescription orders electronically to the care setting via continuity of care document.
This automatically transmits information about the patient’s location, status, demographics and payers to the pharmacy.
The care team can initiate new medications using NewRx and stop discontinued ones using CancelRx.
Using RxChange, the pharmacy can ask questions and the nurse or prescriber can respond electronically.
RxFill confirms that prescriptions sent from the EHR are received from the pharmacy, supporting cycle filling.
Providers can use Resupply to request additional inventory and Drug Administration to suspend and resume prescriptions.
Make prescription management more efficient with clear electronic prescriptions that are structured and standardized to reduce time spent clarifying intent. When prescriptions require follow-up, Surescripts E-Prescribing lets pharmacists address the issue within the electronic workflow through transactions like RxChange, RxRenewal and NewRxRequest to streamline collaboration and get medications to patients sooner.
Enable more cost-effective care with clear, safe prescriptions delivered electronically.
Enable more efficient prescription management with standardized transactions and reducing the need to clarify intent.
Reduce the potential for prescription abandonment, fraud and other safety issues by receiving prescriptions via the highly secure and powerful Surescripts network.
Let pharmacies and providers collaborate on prescriptions within a single workflow, reducing administrative burden and avoiding miscommunication.
The NewRx transaction leverages sophisticated e-prescription fields that reduce the need for follow-up.
Enable RxChange to alert prescribers about generic substitutions and other alternatives, prior authorization and more.
Less need for data entry and follow-up means patients get prescriptions sooner. RxFill keeps the prescriber informed.
Allow pharmacists to send an RxRenewal or NewRxRequest transaction to the prescriber on behalf of the patient.
If the patient changes pharmacy locations, the pharmacy can use RxTransfer to forward the prescription.
Streamline specialty prescribing to improve patient safety by standardizing transactions and clarifying the complex patient instructions often needed for these medications. Collaborate efficiently with prescribers and get patients started on the right medication, and the path to adherence, sooner.
Enable more efficient prescription management by standardizing transactions and reducing the need to clarify intent.
Reduce the potential for prescription fraud and other safety issues by receiving prescriptions via the highly secure and powerful Surescripts network.
Collaborate on prescriptions within a single workflow, reducing administrative burden and avoiding miscommunication.
Use RxRenewal to request prescription renewals and propose updates such as a therapeutic alternative or change in days’ supply with RxChange.
The NewRx transaction leverages sophisticated e-prescription fields that reduce the need for follow-up.
Use RxChange to alert prescribers about therapeutic alternatives, prior authorization and more.
Less need for data entry and follow-up means patients get prescriptions sooner. RxFill keeps the prescriber informed.
Send an RxRenewal or NewRxRequest transaction to the prescriber on behalf of the patient.
If the patient changes pharmacies, use RxTransfer to send the prescription to the new location.
Feature In FocusOur message queue service holds e-prescribing messages in a queue if there is an outage or service interruption that prevents them from being processed by the receiver.
With our message queue service, planned or unplanned disruptions don’t trigger manual work. The service holds prescriptions, then sends them in order once the processer’s system is able to receive them.
Providers don’t need to send faxes or paper prescriptions, pharmacies don’t need to manually enter lost information, and patients may never need to know about the outage at all.
We’re bringing the benefits of Surescripts E-Prescribing to pets and the people who care for them. See how we're using intelligent prescribing to add extra safety, security and efficiency to veterinary prescriptions.
Success Stories“At SigmaCare, we’ve seen time and again how our technology solutions make everything more efficient. This gives the staff more time to devote to the patients, which in turn takes stress off of family.”
Janelle Miller, RN Director of Product Management, Clinical Content and Care Management, SigmaCare“CancelRx provides the alignment of a patient’s prescription information across care provider systems […] and improves our collective ability to ensure that patients are taking the appropriate medication.”
Tolu Akinwale Manager, Electronic Prescribing, Walgreens“Prior to CancelRx, approximately 10% of prescriptions were actually dispensed after that discontinuation in the EHR, and none were following CancelRx implementation.”
Samantha Pitts Assistant Professor, Johns Hopkins University School of MedicineAt a minimum, Surescripts will validate:
All e-prescribing applications sending controlled substance prescriptions are required to provide proof that they have successfully completed a third-party audit according to DEA requirements. This proof of successful audit is required before the application is able to send E-Prescribing for Controlled Substances (EPCS) messages across the Surescripts network.
Before joining the Surescripts network, all participants must complete a certification process that ensures they are using the most recent transaction standards set by NCPDP.
At the start of the prescribing process, the advanced patient matching technology of our Master Patient Index helps confidently identify the correct patient. Once the prescriber enters a prescription, our automation applies structured and codified standards to preserve the intent of the original prescription, clarify patient instructions and reduce the need for manual intervention. We also validate data elements such as National Drug Code so pharmacies can quickly process prescriptions.
The Surescripts network maintains certifications from leading security and privacy organizations including DirectTrust and the Electronic Healthcare Network Accreditation Commission. Strict governance protocols help protect the network from fraudulent activity. Learn more about our commitment to network integrity here.
Our unmatched scale stems from over 20 years of experience connecting prescribers, pharmacies and health plans. That includes proactive planning and alignment around rigorous standards, including guiding the industry through migrations to new NCPDP standards. Today, we maintain 99.995% network uptime while processing 2.5 billion electronic prescriptions a year. 4
Always! We focus on innovations that make a meaningful difference for patients and the people who serve them. To ensure that our intelligent prescribing innovations work in the real world, we convene and consult with diverse stakeholders across healthcare in many different ways. We engage the Surescripts Network Alliance ® in events and 1:1 discussions designed to unlock higher data quality, simplify workflows, improve patient outcomes and evaluate emerging priorities.
We celebrate customers’ prescription accuracy and performance innovations with the Surescripts White Coat Award TM . Beyond the Network Alliance, our heritage of industry leadership includes educating governing bodies on the benefits of e-prescribing, helping deploy and evolve the NCPDP SCRIPT standard and advocating around state policy.
Surescripts is always expanding its partnerships for E-Prescribing. We guide EHRs, health systems and pharmacies step by step through a proven certification process.
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